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AllerMAbs.jpg

艾乐美生物科技有限公司(AllerMAbs Co., Ltd.)成立于2015年,是台湾一家专注于生产高亲和力、高纯度并具有过敏原特异性的嵌合人类IgE单克隆抗体的生物公司。公司创办人团队在科研过程中发现市面上缺乏多样的IgE单克隆抗体,特別是具有过敏原特异性的人IgE 单抗。如果能制备出这种抗体,将有助于IgE 相关领域的研究工作。因此,AllerMAbs公司团队开始思考与研究利用基因克隆动物来制造人类 IgE 抗体的可行性,经过数年的努力于 2014年开发出人类IgE 抗体基因嵌入小鼠,通过杂交瘤技术 (Hybridoma technology),成功地研制出分泌嵌合人类IgE 单抗的 IgE 杂交瘤与纯化 IgE 抗体。经测试,此种嵌合人类IgE 单抗的物化性质与对免疫细胞的活性,皆与人类IgE 抗体一致,研究成果于2015 年发表在国际学术期刊上。

 

AllerMAbs的产品解决了目前人类IgE抗体不易制备的问题,让嵌合人类IgE抗体可以成为人类IgE抗体的替代品,并提供一个更稳定、更符合血清IgE检测系统的校正品,让临床血清IgE的检测结果更加准确与可靠。

 

其利用动物基因转殖技术,将组成人类IgE抗体分子的ε重链(Heavy chain)和κ轻链(Light chain)的编码基因(Encoding genes),分別嵌入(Knock-in)小鼠胚胎干细胞(Embryonic stem cells, ES cells)的γ1重链和κ轻链基因的位置,接着把胚胎干细胞分別植入孕母鼠体内,并将其带有嵌入基因之成鼠交互配种,最后得到带有人类IgE抗体重链和轻链基因的基因嵌入小鼠(HεκKI mice),且体内能制造完整的嵌合人类IgE抗体分子。

 

技术优势

容易制备IgE杂交瘤与IgE单抗

过敏原特异性

良好的亲和力与专一性

高纯度与高稳定性

可结合至嗜碱性粒细胞上的IgE受体与刺激細胞

可大量生产与高浓度制备

非人类血液来源(相较于血清IgE抗体)

适合用作检测用的校正品

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Axon Medchem.jpg

艾美捷科技特约代理Axon Medchem产品。


Axon Medchem的业务之一,是独有的Axon Ligands配体库,在世界范围内,被认为是药物研发的标准。这其中,针对850余种生物靶标(包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等),Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库,Axon Medchem还是欧洲著名的CRO公司,主要针对生物活性分子和药物类似分子展开合成及协议开发工作,在过去的10年中,Axon Medchem已经发现了多种潜在药物分子,并在生物医药界享有一定的声誉。

 

Axon Medchem is a trusted supplier of high-value life science products, providing Axon Ligands™ as world wide recognized drug reference standards for pharmacological research. With more than 2000 excellent quality small molecule inhibitors or modulators targeting more than 850 biological targets of cell signaling, gene transcription, apoptosis, cell cycle regulation, CNS and many more areas, Axon Medchem aims to facilitate your scientific research and development.  

 

Axon Medchem is also a leading European CRO in medicinal chemistry, specialized in contract research and high-quality synthesis of bio-active and/or drug-like molecules. We have the proven record in developing novel drug candidates and achieving excellence for a decade by providing our dedicated chemistry services for companies and research institutes active in the field of life sciences around the world.

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Solulink.jpg

Solulink公司致力于发展高性能的生物分子连接产品,他们不断的努力帮助你保持在生物科学研究的最前沿。可用于任何含有氨基的生物分子标记的ChromaLink™抗体标签试剂盒(ChromaLink™ Antibody Labeling Kit),和One-Shot(单标签)系列试剂盒的成功开发代表着他们始终如一地提供创新产品的承诺,以满足客户不断变化的需求。Solulink公司的产品包括:抗体标签、抗体-寡肽标签、生物素标签、磁珠及凝胶。

 

SoluLinK, Inc. provides linking reagents, conjugation kits, and conjugation services for life science research, diagnostics, and pharmaceutical markets. It offers biotin and digoxigenin labeling, magnetic beads and agarose, biotin and streptavidin, antibody labeling, antibody-oligo labeling, peptide linking and synthesis, and crosslinking products, as well as accessories. The company’s products are used in antibody, nanolink streptavidin magnetic beads, peptide conjugates, protein-peptide conjugates, solid phase peptide immobilization, streptavidin, protein conjugation kits, better biotin, and peplink linkable peptides applications. It offers its products through distributors and licensing partners in Australia, Austria, Belgium, Canada, China, the Czech Republic, Denmark, Finland, France, Germany, India, Ireland, Israel, Italy, Japan, South Korea, the Netherlands, Portugal, the Russian Federation, Singapore, Spain, Sweden, Switzerland, Taiwan, the United Kingdom, and the United States. SoluLinK, Inc. was incorporated in 2000 and is based in San Diego, California.

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艾美捷科技有限公司

全国服务热线:400-6800-868

邮箱:sales@amyjet.com

网站:www.amyjet.com

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Biospacific.jpg


BiosPacific公司是R&D Systems 旗下专门为临床诊断试剂的研发与生产提供抗原、抗体(多抗、单抗、偶联的抗体、抗体对)的公司,在临床诊断试剂方面非常著名,是临床诊断试剂原料的全球供应商。BiosPacific公司是全球著名的临床诊断抗原抗体原料的供应商,其产品主要集中在癌症(肿瘤)、内分泌、传染病、人血清蛋白、甾类、血管病等标记物的优质单抗、多抗、抗原、偶联抗体,以及抗体对(matched pairs)。

 

As a manufacturer and supplier of antibodies and antigens of exceptional quality, for more than 29 years, BiosPacific is experienced in meeting the rigorous demands of the industrial client. Our success has been due, in large part, to our commitment to find the most effective solutions for your individual needs. Our expansive range of monoclonal antibodies, affinity purified polyclonal antibodies and purified proteins for immunoassay development allows us to support our customers collaboratively from feasibility to manufacturing. Browse by subject category such as cancer or cardiac markers below, or do a keyword search using the search field above.

 

BIOSPACIFIC产品的主要涵盖领域:

(1)Cancer

AFP, Alpha-2 Macroglobulin, Beta-2 Microglobulin, CA 125

(2)Endocrine Thyroid

ACTH, FSH, hCG, hGH, IGF-1, Insulin, LH, Proinsulin

(3)Steroids

Cortisol, Estradiol, Progesterone, Testosterone

(4)Cardio-vascular

CKBB, CKMB, CKMM, CRP, D-dimer, Myoglobin, TNI

(5)Human Serum Proteins

Albumin, Alpha-1 Antitrypsin, APO E,CRP, Hemoglobin

(6)Miscellaneous

Ferritin, Glucagon, IgE Myeloma Plasma, Stripped Serums, TPO

(7)Drugs

Amikacin, Amphetamine, Barbiturate, Benzodiazepine

(8)Infectious Diseases

Adenovirus, Chlamydia, CMV, Influenza A & B, HAV, HBcAg, Zika

(9)Medix Biochemica

AFP, CEA, CKMB, IgA, Myoglobin, RSV, SHBG, TSH

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